|Year : 2017 | Volume
| Issue : 2 | Page : 142-146
Diagnostic reference levels for computed tomography of the head in Anambra State of Nigeria
Thomas Adejoh1, Christian C Nzotta2, Michael E Aronu1, Musa Y Dambele3
1 Department of Radiology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria
2 Department of Radiography and Radiological Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
3 Department of Radiography, Bayero University, Kano, Nigeria
|Date of Web Publication||20-Jul-2017|
Department of Radiology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State
Background: Diagnostic reference levels (DRLs) were first conceptualized in 1996 by the International Commission on Radiological Protection as a result of wide variations in patient dose levels for the same examination. Current works on computed tomography (CT) doses in Nigeria produced significant variations. These observed variations, coupled with unavailable national or regional DRLs have presented the need for the establishment of standards through a dose survey.
Objective: The aim of this study is to establish DRLs for CT of the head in adult populations of Anambra State of Nigeria.
Materials and Methods: The retrospective survey was carried out from February to June 2016 in the four busiest CT centers. The digital CT population considered was those of subjects examined in 2015, and who were aged ≥18 years. Two hundred folders, comprising fifty from each center were included. The on-screen volume computed tomography dose index (CTDIvol) and dose-length product (DLP) for the subjects were recorded. The 75th percentile was then calculated for each center to establish center-specific DRLs. Finally, a combined 75th percentile of the CTDIvoland DLP for all centers was calculated to establish the DRLs for the state. Data were analyzed using SPSS version 20.0 (SPSS Incorporated, Chicago, Illinois, USA).
Results: The digital folders of 104 male and 96 female subjects with age range of 18–93 years were analyzed. The specific 75th percentile of the CTDIvol and the DLP of the centers ranged from 46 to 86 milligray (mGy) and 794 to 1785 mGy centimeters (mGy-cm), respectively. The DRLs for the State are 66 mGy and 1444 mGy-cm, respectively.
Conclusion: The DRLs for head CT in Anambra State has been derived. Although the CTDIvolis comparable to the recommendations of the European Commission, the DLP is significantly higher. Further training on dose optimization may help to bring the radiation dose in the locality at par with foreign values.
Keywords: Computed tomography, computed tomography protocol, dose, dose-length product, volume computed tomography dose index
|How to cite this article:|
Adejoh T, Nzotta CC, Aronu ME, Dambele MY. Diagnostic reference levels for computed tomography of the head in Anambra State of Nigeria. West Afr J Radiol 2017;24:142-6
|How to cite this URL:|
Adejoh T, Nzotta CC, Aronu ME, Dambele MY. Diagnostic reference levels for computed tomography of the head in Anambra State of Nigeria. West Afr J Radiol [serial online] 2017 [cited 2021 Mar 4];24:142-6. Available from: https://www.wajradiology.org/text.asp?2017/24/2/142/206806
| Introduction|| |
Diagnostic reference levels (DRLs) were first conceptualized in 1996 by the International Commission on Radiological Protection as a result of wide variations in patient dose levels for the same examination., They are intended for use as a simple test for the identification of abnormally high dose levels by setting an upper threshold, beyond which the imaging technique must be optimized to reduce radiation dose.
The third quartile of each examination included in a dose survey is considered as the acceptable yardstick for DRL., Local and regional DRLs are advised as the use of foreign ones are inadequate due to the dissimilar region-specific training of the radiographers, as well as variations in the equipment and populations used in establishing them.
The International Electrotechnical Commission recommended the volume computed tomography dose index (CTDIvol), and dose-length product (DLP) as the dosimetrics for computed tomography (CT). The CTDIvol, with a unit of milligray (mGy), is a standardized measure of the radiation output in a single slice of a CT scanner which allows users to compare different scanners and scan protocols. DLP combines the CTDIvol(mGy) and the scan range (cm) to quantify the total radiation dose received by the patient during a CT scan and is given in mGy centimeters (mGy-cm) [Figure 1].
|Figure 1: Series “999” showing the dose report at the end of the investigation. There are two “CTDIvol” because two slice thickness were used to acquire images. The dose-length product always come as a composite value irrespective of the diversity of slice thickness and number of series. The image anonymity feature on general electric scanners is accessed through the “user preference” icon|
Click here to view
A survey of CT doses in four continents and covering forty countries indicated that brain CT is the most common examination. The prevalence of these dose surveys are however, higher in Europe than in other continents. In a pioneering role, the European Commission made widespread recommendations on DRL for its member countries with an adult CTDIvol of 60 mGy and DLP of 1050 mGy-cm for head CT examinations. Similar recommendations in African countries are sparse, and where available, they are specific to pediatrics,, the mean, rather than the third quartile, are used,, or comparatively higher CT doses are reported for various examinations.,
In Nigeria, in spite of the large number of examinations carried out yearly, the dose information available is grossly inadequate. In addition, there is no evidence of published data indicating the establishment of national DRLs (nDRL) of common examinations in the country. A published northern survey, had significant variations from two other local center-specific studies,, and with the recommendations of the European Commission. These observed variations, coupled with unavailable nDRLs have presented the need for the establishment of a national standard. The establishment of DRL for a country will involve surveys from its composite regions., The present survey, which aims to establish DRLs for adult head CT examinations, is, therefore, contemplated for a region of Nigeria.
| Materials and Methods|| |
The design of the work was retrospective, and it involved digital images. Ethical approval from a Teaching Hospital (NAUTH/CS/66/Vol 8/84/of 24-02-2016) and written permissions from all centers to undertake the study were obtained. The survey was carried out from February to June 2016, in a teaching hospital (A), an Anglican Church-owned tertiary hospital (B), a Catholic Church-owned tertiary hospital (C) and a large private diagnostic center (D). Three of the centers are located in Onitsha while one is in Nnewi. Two other privately-owned centers in Onitsha and Nnewi were excluded as they lacked on-screen CTDIvol and DLP dosimetrics.
A general electric BrightSpeed, 4-slice scanner manufactured in 2007 and installed in 2011 was available at center A. Both centers B and C had a similar Toshiba Alexion, 16-slice scanners manufactured in 2013 and installed in 2014. The private diagnostic center had a 16-slice Siemens Somaton-Perspective scanner manufactured and installed in 2015. The scanners in centers A and D were installed and programmed by different engineers while the same people installed and programmed the ones in centers B and C. All the scanners had helical and axial scan modes. The variations in protocols were minimal, and it was not gender biased. The arrangement of the knobs however, varied substantially with the make of the scanner. The scanners were also self-calibrating, and these system software were activated daily. All centers had licensed Radiographers and reporting Radiologists. The newest center had scanned for at least 6 months before the commencement of the survey.
One hundred and four male and 96 female digital folders (n = 200) of subjects aged 18–93 years were involved. The head requests were in three broad categories of cranium (n = 164), sinuses (n = 30) and facial bones (n = 6). The four centers utilized a range of tube potential and tube current of 120–140 kVp and of 220–250 mA, and a modal gantry rotation time of 1 s. Aside center A with adjustable tube current mode, all the other centers operated with a fixed (automatic) mode.
The researchers accessed the digital folders for 2015 on the console and purposively sampled out the head CT population who were ≥18 years. Confidentiality of digital information was maintained by the activation of data anonymity features of the scanner to mask every information except age, gender, and date of scan. The folders were examined sequentially and those with scanograms which were generated in supine position, at an azimuth of 90° and 180°, respectively, and with no evidence of bandages, scalp edema or distortion of bony skull tables or facial bones were included. Folders containing acceptable images but with gross noise, as noted by the Radiologist, were omitted. Those also rejected by the Radiologists due to noise and artifacts were excluded.
A minimum of ten cases is considered adequate for the purpose of DRL., However, fifty subjects were included in each center surveyed. The CTDIvol and DLP which is represented on all scanners as series “999” were recorded for the subjects. The mean, mode and 75th percentile was then calculated for each center to establish center-specific DRL. Subsequently, the combined mean, mode and 75th percentile for all centers was calculated to establish the DRL for the State. Data were analyzed with the aid of computer software, SPSS version 20.0 (SPSS Incorporated, Chicago, Illinois, USA).
| Results|| |
The digital folders of 104 male and 96 female subjects with age range of 18–93 years were analyzed. Cranial examinations dominated the requests (82%). The modal gantry rotation time used by all centers was 1 s while the tube current (220–250 mA) and tube potential (120–140 kVp) were consistently variable. Aside center A, the other centers programmed their scanner for automatic tube current modulation (auto mA). These are summarized in [Table 1]. The center-specific 75th percentile of the CTDIvol and the DLP ranged from 46 to 86 mGy and 794 to 1785 mGy-cm, respectively. The composite DRLs are 66 mGy and 1444 mGy-cm, respectively [Table 2]. A comparison with the European Commission values and other foreign works gave a significant variation of 1.5%–52% (CTDIvol) and 27.3%–41.1% (DLP) is shown in [Table 3].
| Discussion|| |
The use of DRL for various patient conditions can be helpful in risk-benefit evaluation. Our analyses yielded a significantly variable center-specific CTDIvol and DLP values of 46–86 mGy and 794–1785 mGy-cm, respectively. This variability is often the indication for the establishment of a common DRL. Our combined CTDIvol and DLP were 66 mGy and 1444 mGy-cm, respectively.
Our CTDIvol is comparable to works from Europe, Canada as well as the European Commission. However, a comparison with a local multi-center survey, showed a moderate variation of 14.3% in CTDIvol and a considerable variation of 32% in DLP. Since both works emanated from the same locality, the need for a national DRL is, therefore, imperative to bridge the gap.
The volume CTDI is substantially influenced by the tube current-time (mAs) and tube voltage (kVp), which collectively make up the intensity of radiation,, and also by pitch and collimation. When these parameters are kept constant as often happens in automatic tube current modulation, a similar CTDIvol ensues irrespective of patient size or anatomical area scanned. Automatic tube current modulation is a strategy for fluctuating the mAs in tandem with the thickness of the anatomy and for keeping CTDIvol constant in spite of that, and three of the centers surveyed operated in that mode. If the system is programmed ab initio with skillful optimization technique, the tendency for dose drop is high as shown by the output from center D.
The skill of the radiographer and their knowledge of radiation dose are relevant in setting up the optimal intensity combination that will reduce radiation dose while still producing images with minimal noise and of high diagnostic quality. The convention of looking up to Europe for guidance and the experience of using similar roving CT engineers in the locality may have been responsible for the similarity in kVp of 120 used as well as the fairly similar mA applied. A kVp of 120 kVp rather than 140 will lead to 20%–40% reduction in patient dose.
However, while centers A (60 mGy) and B (59 mGy) had comparable CTDIvol, centre C had the highest while center D (32 mGy) was the lowest and was fairly comparable to the work from India. It was observed that the radiographers in centers C and D rarely adjusted their protocols as they depended exclusively on the default protocols. Centers B and A however, often manipulated their protocols in response to the age and weight of patients. Although the CTDIvol of center D appeared very low, its wide variation from other works calls for a protocol audit. The derived CTDIvol of 66 mGy for the locality is, therefore, appropriate as it shows minimal variation (<10%) from the works from Taiwan, Canada, and Europe.
The DLP is a combination of radiation intensity and scan range., Irrespective of the value of the CTDIvol or the slice capacity of the scanner, a minimal scan range produces a small value of DLP. The <1000 mGy-cm recorded for centers A and D and >1400 mGy-cm for centers B and C are expectedly as a result of decreased and increased ranges, respectively. Centre C (1785 mGy-cm) with about 19% variation from the common DLP (1444 mGy-cm) is almost an extreme statistical outlier. Dose audit convention, however, does not encourage the exclusion of any center which has met the inclusion criteria.,
The extent of body length covered in scanning does not affect the CTDIvol value but certainly affects DLP. The scanning length for a particular type of CT examination can vary due to the pathology of the patient, the size of the patient, and the experience of the user. For all these reasons, CT protocols need to be reviewed so as to limit irradiation only to the collimated area of the anatomy under investigation.
The justification for optimizing the CTDIvol and DLP from this locality to a comparable level with foreign ones is clear; the present work revealed considerable variation of the CTDIvol(1.5%–52%) and DLP (27.3%–41.1%) from popular works from other countries.,,, Although there were also variations among those works, it was within narrow limits. Achieving this comparable dose levels would need the synergy of requesting Physicians, Radiologists, and Radiographers. They should by all means desire optimum image quality, but that interest should go parri passu with a keen concern for the radiation dose their patients are subjected to.
| Conclusion|| |
The DRLs for adult head CT scans for the population are 66 mGy and 1444 mGy-cm. Centers with fairly lower values of the DLP are more adept at optimization and should retain their values. A DRL that is exactly comparable to international recommendations is achievable in our locality if regular dose audit is carried out.
The observed inter-center variations in the same locality calls for standardization of training and, or regular peer review of procedures with other centers. Also, requesting Physicians and Radiologists should demand dose output as a slide in the printed films. The Radiologists are also strongly urged to comment on the appropriateness of radiation dose used for the investigation, in their reports. This will place a strong moral and professional obligation on Radiographers to pay more attention to dose optimization. Requesting Physicians and reporting Radiologists are also advised to minimize their desire for lengthy adjoining anatomy to be captured during scan. A maximum adjoining anatomy of 10 mm is advised. Furthermore, a national DRL that will place an ethical obligation on the CT community is strongly recommended.
Radiographers in all the centers and Radiology Residents in Centre A.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Radiological protection and safety in medicine. A report of the International Commission on Radiological Protection. Ann ICRP 1996;26:1-47.
Wall BF, Shrimpton PC. The historical development of reference doses in diagnostic radiology. Radiat Prot Dosimetry 1998;80:15-9.
Foley SJ, McEntee MF, Rainford LA. Establishment of CT diagnostic reference levels in Ireland. Br J Radiol 2012;85:1390-7.
Gray JE, Archer BR, Butler PF, Hobbs BB, Mettler FA Jr., Pizzutiello RJ Jr., et al.
Reference values for diagnostic radiology: Application and impact. Radiology 2005;235:354-8.
Olarinoye IO, Sharifat I. A protocol for setting dose reference level for medical radiography in Nigeria: A review. Bayero J Pure Appl Sci 2010;3:138-41.
International Electrotechnical Commission. Medical Electrical Equipment-Part 2-44: Particular Requirements for the Safety of X-ray Equipment for Computed Tomography. Geneva, Switzerland: IEC; 2002.
McCollough CH, Leng S, Yu L, Cody DD, Boone JM, McNitt-Gray MF. CT dose index and patient dose: They are not the same thing. Radiology 2011;259:311-6.
Vassileva J, Rehani MM, Al-Dhuhli H, Al-Naemi HM, Al-Suwaidi JS, Appelgate K, et al.
IAEA survey of pediatric CT practice in 40 countries in Asia, Europe, Latin America, and Africa: Part 1, frequency and appropriateness. AJR Am J Roentgenol 2012;198:1021-31.
Martin CJ, Le Heron J, Borrás C, Sookpeng S, Ramirez G. Approaches to aspects of optimisation of protection in diagnostic radiology in six continents. J Radiol Prot 2013;33:711-34.
European Commission Guidelines on Quality Criteria for Computed Tomography. Report EUR 16262 EN. Luxembourg: Office for Official Publications of the European Commission; 1999. p. 66-78.
Vawda Z, Pitcher R, Akudugu J, Groenewald W. Diagnostic reference levels for paediatric computed tomography. S Afr J Radiol 2015;19:1-4.
Gedel AM, Gablah PG. Management of radiation dose to pediatric patients undergoing CT examination at Korle-Bu Teaching Hospital, Accra – Ghana. Adv Phys Theor Appl 2014;37:30-7.
Wambani JS, Korir GK, Onditi EG, Korir IK. A survey of computed tomography imaging techniques and patient dose in Kenya. East Afr Med J 2010;87:400-7.
Ngaile JE, Msaki PK. Estimation of patient organ doses from CT examinations in Tanzania. J Appl Clin Med Phys 2006;7:80-94.
Muhogora WE, Ahmed NA, Beganovic A, Benider A, Ciraj-Bjelac O, Gershan V, et al.
Patient doses in CT examinations in 18 countries: Initial results from International Atomic Energy Agency projects. Radiat Prot Dosimetry 2009;136:118-26.
Ogbole G, Obed R. Radiation doses in computed tomography: Need for optimization and application of dose reference levels in Nigeria. West Afr J Radiol 2014;21:1-6. [Full text]
Garba I, Engel-Hills P, Davidson F, Tabari AM. Computed tomography dose index for head CT in northern Nigeria. Radiat Prot Dosimetry 2015;165:98-101.
Abdullahi M, Shittu H, Joseph D, Aribisala A, Eshiett EP, Itopa R, et al
. Diagnostic reference level for adult brain computed tomography scans: A case study of a tertiary health care center in Nigeria. IOSR J Dent Med Sci 2015;14:66-75.
Osei EK, Darko J. A survey of organ equivalent and effective doses from diagnostic radiology procedures. ISRN Radiol 2012;2013:204346.
Tonkopi E, Abdolell M, Duffy S. Establishment of CT diagnostic reference levels in province Nova Scotia. Med Phys 2015;42:32-49.
Saravanakumar A, Vaideki K, Govindarajan KN, Jayakumar S. Establishment of diagnostic reference levels in computed tomography for select procedures in Pudhuchery, India. J Med Phys 2014;39:50-5.
] [Full text]
Tsai HY, Tung CJ, Yu CC, Tyan YS. Survey of computed tomography scanners in Taiwan: Dose descriptors, dose guidance levels, and effective doses. Med Phys 2007;34:1234-43.
Brix G, Nagel HD, Stamm G, Veit R, Lechel U, Griebel J, et al.
Radiation exposure in multi-slice versus single-slice spiral CT: Results of a nationwide survey. Eur Radiol 2003;13:1979-91.
Sistrom CL. The ACR appropriateness criteria: Translation to practice and research. J Am Coll Radiol 2005;2:61-7.
Tipnis S, Thampy R, Rumboldt Z, Spampinato M, Matheus G, Huda W. Radiation intensity (CTDIvol) and visibility of anatomical structures in head CT examinations. J Appl Clin Med Phys 2016;17:5701.
Goo HW, Suh DS. The influences of tube voltage and scan direction on combined tube current modulation: A phantom study. Pediatr Radiol 2006;36:833-40.
Aweda MA, Arogundade RA. Patient dose reduction methods in computerized tomography procedures: A review. Int J Phys Sci 2007;2:1-9.
Kopp AF, Heuschmid M, Claussen CD. Multidetector helical CT of the liver for tumor detection and characterization. Eur Radiol 2002;12:745-52.
Wildberger JE, Mahnken AH, Schmitz-Rode T, Flohr T, Stargardt A, Haage P, et al.
Individually adapted examination protocols for reduction of radiation exposure in chest CT. Invest Radiol 2001;36:604-11.
[Table 1], [Table 2], [Table 3]
|This article has been cited by|
||DOSE BENCHMARKS FOR PAEDIATRIC HEAD COMPUTED TOMOGRAPHY EXAMINATION IN NIGERIA
| ||Ernest Usang Ekpo,Thomas Adejoh,Akwa Egom Erim |
| ||Radiation Protection Dosimetry. 2019; |
|[Pubmed] | [DOI]|
||Computed tomography scanner census and adult head dose in Nigeria
| ||Thomas Adejoh,Emeka Christian Onwujekwe,Mohammed Abba,Alhaji Modu Ali,Ama Samuel Imo,Christian Chukwuemeka Nzotta,Hyacienth Uche Chiegwu |
| ||The Egyptian Journal of Radiology and Nuclear Medicine. 2018; |
|[Pubmed] | [DOI]|
||Diagnostic reference levels for common computed tomography (CT) examinations: results from the first Nigerian nationwide dose survey
| ||Ernest U Ekpo,Thomas Adejoh,Judith D Akwo,Owujekwe C Emeka,Ali A Modu,Mohammed Abba,Kudirat A Adesina,David O Omiyi,Uche H Chiegwu |
| ||Journal of Radiological Protection. 2018; 38(2): 525 |
|[Pubmed] | [DOI]|