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CASE REPORT
Year : 2017  |  Volume : 24  |  Issue : 1  |  Page : 109-115

A case series of tuberous sclerosis complex: Clinico-radiological study and review of the literature


Department of Radio diagnosis, Imaging and Interventional Radiology, N.S.C.B. Subharti Medical College, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India

Correspondence Address:
P K Gupta
108-109, Chanakyapuri, Shastri Nagar, Meerut - 250 004, Uttar Pradesh
India
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DOI: 10.4103/1115-3474.198155

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Introduction: Tuberous sclerosis complex (TSC) is a relatively rare autosomal dominant disorder characterized by a variety of hamartomatous lesions in various organs. The diagnosis is usually established on the basis of diagnostic criteria related to clinical and/or radiologic findings. Since the classical Vogt triad of seizures, mental retardation, and adenoma sebaceum are seen in only a minority of cases, radiology plays an important role in diagnosis of the disease. The aim of the study is to evaluate the clinico-radiological pattern in this disease. Materials and Methods: A clinical and radiological evaluation of 4 cases of suspected TSC was conducted within a period of 18 months. Results: All the four patients were below 25 years of age. Two patients were female and two were male. All the 4 patients had a history of seizures, while 2 also had mental retardation. One patient had hypomelanotic macules. On imaging, all the 4 patients showed neurological involvement in the form of cortical tubers, subependymal nodules, and white matter abnormalities while only one patient showed radial migration lines. One patient additionally showed the presence of cardiac rhabdomyoma. Conclusion: In addition to clinical examination, imaging plays a very important role in identifying the abnormalities of TSC and other additional features.


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